Extract from broccoli medicine. BAA Mirax Indinol - “Are you still taking hormonal drugs? Broccoli against women's problems!

Did you know that broccoli should be included in your daily diet? Well, let's go the other way: do you know about the benefits of the drug "Indole Forte"? If you want to know what cabbage and indole have in common, then read on our article on how to prevent tumors, mastopathy and get rid of papillomas.

Ancient healers said that for every disease, God on Earth created a plant that would cure it. Broccoli is one such healthy vegetable: it contains natural indole, which defeats tumors and prevents them from forming.

It is known that each organism is capable of provoking the growth of malignant cells, especially if its immune system is weakened, and papillomas on the skin are the first alarm bells. Remember, if you see these "warts on the legs", then the next step may be mastopathy, fibroids or other problems associated with tumors.

The reason for this is the human papillomavirus, which is sexually transmitted and does not manifest itself in any way, except for malignant tumors. There are special tests that can detect this virus, but if your skin is strewn with "icicles", then everything is clear.

For a long time, human papillomavirus was not associated with serious diseases and did not know how to catch it, and now every teenager who begins sexual activity is at risk of contracting the virus and becoming predisposed to cancer. To prevent this among young people, there are condoms and a plate of broccoli cabbage every day on an empty stomach or 1 capsule of the drug "Indole Forte". Choose! The future of your own children is in your hands. If you're wondering what's good about broccoli in capsules or in its natural form, then read on.

"Indole forte" - a must-have drug for the whole family

The active substance in this product is called indole-3-carbinol - it is an extract from radish vegetables, everything (especially broccoli), radish, swede. For the prevention of tumor diseases, as well as female and male diseases of the pelvic organs, it is recommended to eat about 400 grams of these vegetables daily. The manufacturer of the drug "Indole Forte" offers an alternative - taking 1 capsule per day for all family members to prevent dangerous diseases or undergoing a comprehensive course of treatment with the participation of this remedy.

The prophylactic course lasts a month and can be repeated if desired. No side effects have been identified, the drug can be taken both for treatment and for the prevention of tumors. The drug "Indole forte" showed itself well in the fight against cancer of the uterus, breast and mastopathy of any form. For existing problems, it is recommended to add a product based on an extract from plants of the cruciferous family to the pharmaceutical treatment regimen.

"Indol forte": price

The drug is sold in pharmacies without a prescription as a phytotherapeutic agent or dietary supplement. The cost of one package containing 30 capsules is about $15. One package is enough for a month, that is, for a course of preventive treatment. Discuss individual dosages with your doctor.

At the moment, it is possible to buy drugs containing indole in an online store, which makes life much easier for customers: you just need to choose the manufacturer you like and the price of the product, and after a few days a jar of broccoli extract will be on your table.

We wish you health and only preventive treatment.

Broccoli cabbage is a plant that resembles a small, stumpy tree, but it is completely different from cabbage, although it is one of the most useful members of the family. cruciferous (Cruciferae) or cabbage.

The Italian name for the vegetable is "broccolo", which means "flowering top of the cabbage". This word comes from the Latin "brachium" - "branch" or hand, a reflection of the tree-like form of the plant. The plant came to France in 1560, and to England - only at the beginning of the 18th century. The British called the vegetable simply and uncomplicated "Italian asparagus."

Today, the popularity of broccoli is obvious. It is cultivated all over the world. China, the largest producer, grows more than 8 million tons per year.

On the vegetable market you can find hybrids: "broccolini" (participated in its creation Chinese cabbage gai-lin) and "broccoflower" (a hybrid of broccoli and cauliflower).

This cabbage should be present in the diet of all women and men with health problems. It contains useful material, normalizing the production of insulin, so the product should be present in the menu of diabetics and sweet tooth.

Also found in broccoli is a compound that promotes the production of endorphin, a neurotransmitter that improves mood.

• Vitamin profile: A, C, E, K, group B: B1 (thiamine), B2 (riboflavin), B3 (PP or niacin), B5, B6, B9, vitamin-like substance U.
• Macro- and microelements: zinc and iron, potassium and calcium, selenium, phosphorus, sodium and manganese.
  The introduction of broccoli into the diet on a regular basis will reduce the proportion of animal products without harming the body. This vegetable is suitable for various diet programs, as it really helps in losing weight.

vegetable benefits

The health benefits of broccoli have been backed up by numerous scientific studies.

Against oncological diseases

Notes periodically appear in the news feed about the next discovery of scientists related to the antitumor properties of broccoli.

Scientists from the University of Michigan have found that the sterols that make up the product help reduce the risk of developing certain types of breast tumors in women. Also, this vegetable crop reduces the risk of developing prostate cancer in men.

• Broccoli contains sulforaphane, which has strong antioxidant properties and prevents the development of malignant cells. Other sources of this compound are cauliflower and Brussels sprouts.
• In addition, this wonderful cabbage contains many of the plant's more common antioxidants, such as vitamin C.
• The vegetable also gives a strong anti-inflammatory effect: scientists note a correlation between internal inflammation and the development of malignant tumors.
• Broccoli improves bowel function, which also reduces the risk of neoplasms in the intestinal tract.
• Selenium, which is rich in cabbage, removes heavy metal salts and carcinogens from the body.

Want to protect yourself and your loved ones from cancer? Diversify the menu with broccoli. Choose young sprouts - according to experts, they contain the maximum doses of sulforaphane.

The compound is found in fresh green cabbage sprouts in an inactive form and, only when it enters the human body under the action of saliva and intestinal enzymes, it manifests its properties. For this reason, the concentration of sulforaphane in the body, as well as its effectiveness, depends on physiological characteristics.

By the way, now British scientists are trying to develop a variety of broccoli with increased anti-cancer properties.

For the gastrointestinal tract

• Broccoli and its juice contribute to the normal production of bile, which helps to digest food with reduced function or deformity of the gallbladder.
• Cabbage destroys bacteria in the stomach that cause gastritis and ulcers. But, even if the stomach disease is caused by increased nervousness or malnutrition, broccoli will still help. The vegetable contains compounds that help restore the mucosa and heal the peptic ulcer.
• Cabbage normalizes the functioning of the nervous system and helps to cope with gastritis, provoked by nervous shocks.
• A large amount of fiber normalizes bowel function, cleanses the digestive tract and stimulates weight loss.
• This is an excellent food for those who have survived an intestinal infection. The vegetable saturates, is easily digested and neutralizes the harm caused by pathogens. Another product normalizes the water-electrolyte balance, which is inevitably disturbed by food poisoning.

For the circulatory system

The beneficial properties of this cabbage are important for people suffering from cardiovascular ailments. The product contains a lot of protein, similar in structure to protein chicken egg. At the same time, there is no cholesterol in broccoli, and the amount of fat is trace. To cleanse the blood and sparing weight loss, you can drink green cabbage juice or a decoction.

• The vegetable has a lot of chlorophyll, which has a beneficial effect on the composition of the blood.
• Methionine and choline remove cholesterol from the blood and prevent its accumulation in the form of plaques.
• Copper is essential for the normal process of hematopoiesis.
• A significant amount of magnesium and potassium, as well as protein, helps in strengthening the heart muscle.

For lung health

Proven benefits of broccoli for the respiratory system.

• The anti-inflammatory properties of the vegetable will help asthmatics. And all thanks to the same sulforaphane.
• Helps to cope with pathogens in the lungs. This is especially true for smokers who have a weakened immune system and whose natural defenses do not work well. In this case, sulforaphane takes on the role of human macrophages - white blood cells that fight infection.
• Broccoli will also be useful for people with chronic lung diseases such as bronchitis and emphysema.

For beauty and weight loss

Broccoli is a popular vegetable among women who care about their appearance.

• The product is used for weight loss, as it normalizes digestive processes and has a low calorie content.
• Manganese and zinc are good for skin health.
• Beta-carotene slows down the aging process of cells.
• Broccoli, as well as juice and decoction from it, remove toxins from the body, cleanse the intestines and prevent putrefactive processes and disorders in the digestive tract - all those phenomena that most often cause acne, skin irritation and unhealthy complexion.
• It removes excess fluid from the body (an inevitable companion of edema and cellulite), which contributes to weight loss.
• Folic acid stimulates the birth of new cells, thereby helping to renew the covering tissues, including the skin.
• Cabbage is rich in vitamin E, which makes the skin supple, firm and rejuvenated.

But in order for the product to bring only benefit and no harm, it is important to apply healthy recipes in which broccoli is used in fresh for salads, boiled or steamed.

For expectant mothers

Broccoli is amazing healthy cabbage for women who have decided to experience the joy of motherhood.

• Vitamin E, together with other vitamins and microelements, is necessary for successful conception and smooth pregnancy, and brings tangible benefits to the female reproductive system.
• The vegetable provides building material for the child's body without compromising the health of the mother.
• As you know, the fetus "pulls" useful substances from the mother's body, including calcium. Because of this, women have problems with their teeth. But there is a lot of calcium in broccoli. And if mom eats cabbage regularly, her teeth are safe.
• The product contains a lot of folic acid (vitamin B9), which is necessary for both mother and child. Children need it for the normal development of the nervous system, the formation of tissues and organs. And mom will help to endure pregnancy, while maintaining a positive attitude.

For men

The benefits for the body of men are also significant, since the vegetable:

• improves the composition of sperm and reduces the risk of developing prostate cancer;
• contains a significant amount of vitamin A, necessary male body for strong immunity, keen vision and health of the bone skeleton;
• is a good source of vitamin C, which is especially important for the stronger sex for rapid regeneration in case of injuries and wounds.

For babies

Broccoli puree is an excellent food for babies older than six months. Since this cabbage is considered hypoallergenic, it is one of the first to be introduced into complementary foods for children. It is easily digested immature digestive system baby, providing him with a whole range of nutrients.

You can make your own puree or buy it ready-made. children food by choosing from a large number of offers on the Russian market.

Not to be left without healthy vegetable in winter, mothers freeze green inflorescences for the future: if necessary, they can be easily thawed using a double boiler.

How to cook

The medicinal properties of broccoli will be fully manifested if you use it raw or get freshly squeezed juice (fresh) from it. Frozen cabbage will also retain benefits.

Not everyone likes the taste of raw cabbage, so housewives have to be cunning.

Broccoli can be used to make healthy, refreshing smoothies. It is recommended to combine it with cauliflower, apples and celery. Just grind all the ingredients in a blender. Such juice can be used for weight loss or thirst quenching.

Broccoli can be used vegetarian recipes fondue dipped in melted cheese.

a little less good bring boiled, oven-baked or steamed cabbage. But even in this form, it will render your health a great service.

But frying green inflorescences with a lot of oil is not recommended. Especially if you are afraid of carcinogens.

Without exception, it is contraindicated for everyone to drink a decoction left over from cooking broccoli; it can be harmful, as it contains substances dangerous to humans: adenine and guanine. For the same reason, the vegetable is not suitable for cooking. vegetable broths and soups.

But there is an exception: broccoli puree soups are very healthy and tasty if you follow the recipe. But they mean cooking on a vegetable or chicken broth(cabbage inflorescences are boiled separately).

If you are considering using broccoli for its anti-cancer properties, take your time to cook it.

In 2007, a study was conducted at the University of Warwick. Experts studied the effect of boiling, steaming, cooking in microwave oven and frying for the safety of anti-cancer substances in the composition of the vegetable. It turned out that boiling led to the biggest losses. Whereas steaming for 20 minutes, microwaving for 3 minutes, and frying for 5 minutes did not result in a significant loss of anticarcinogenic compounds.

Of course, raw broccoli retains all of its beneficial nutrients. But it can irritate the intestines and cause increased gas formation.

Harm and contraindications

Any cauliflower has contraindications. It can harm patients:

• in violation of the functions of the pancreas;
• with gastritis with high acidity.

Some postoperative diets have contraindications for high fiber intake. In this case, the ban will apply to many vegetables and fruits.

If you are deeply uncomfortable with the taste of this cabbage, you may need to check with an endocrinologist. Doctors believe that aversion to broccoli is often associated with iodine deficiency in the body and disorders in the thyroid gland. The fact is that the vegetable contains a large number of glycosinolates that interfere with the synthesis of iodine-containing compounds in the human body. Fortunately, when broccoli is cooked, this property loses its relevance.

And for some, especially sensitive people, when green inflorescences come into contact with the skin, an allergic rash may appear.

Sulforaphane is an anti-cancer compound found in cruciferous vegetables, found in the highest amounts in broccoli. Able to have an anti-inflammatory effect similar to the action of curcumin. Also known as broccoli extract.

Not to be confused with diindolylmethane (also found in broccoli).

Sulforaphane, found in broccoli and other vegetables, is sensitive to high temperatures.

Sulforaphane instruction

Although the optimal dosage has not been determined, doses of 1-0.5mg/kg sulforaphane have been shown to be bioactive in mice. The following are preliminary dosages for humans:

1.1-5.5mg for people over 67kg

1.5-7.3mg for people over 90kg

1.8-9.1mg for people over 112kg

This amount of the substance can be ingested by eating raw broccoli or other vegetables, but the dosage is not limited, since the optimal amount of sulforaphane for humans has not been established.

Sources and structure

Sulforaphane in food

Sulforaphane is found in food products in the form of glucoraphanin, glycoside, or simply sulforaphane. Glucoraphanin is one of several molecules called isothiocinates. Such molecules are found in cruciferous vegetables along with synirgin (metabolized to allyl isothiocyanate), glucuronide (metabolized to benzyl isothiocyanate), gluconasturthine (metabolized to phenethylisothiocyanate) and glucobrassicin (metabolized to diindolylmethane). Sources of sulforaphane and/or glucoraphanin are:

Sulforaphane is an active isothiocyanate found in food products.

digestion and catabolism

Sulforaphane is found in foods in the form of glucoraphanin (4-methylsulfinylbutyl glucosinolate), the glucose residue on which is removed by myrosinase (thioglucoside glucohydrolase), an enzyme found in plants such as broccoli, and also promotes the conversion of other glucosinolates such as glucobrassicin to indole-3- carbinol (which is subsequently converted to diindolylmethane). When myrosinase acts on glucoraphanin, an unstable intermediate is produced; if the protein's epithiospecifier (EPS) is active, it is able to convert the substance to sulforaphane nitrile (5-methylsulfinylpentane nitrile), which has no anti-cancer properties. At low ESB activity, the only possible transformation of this unstable intermediate is to sulforaphane.

Receipt

Short-term heating can destroy the natural properties of ESB and increase the amount of sulforaphane in broccoli by reducing the metabolism of glucoraphanin. Excessive heat contributes to the destruction of myrosinase, which leads to the disappearance of sulforaphane in the product; while deactivation of myrosinase by excessive heat results in a lack of sufficient sulforaphane, relative heat treatment retains sulforaphane, which is achieved by balancing the temperatures of exposure to ESB and myrosinase. When heating broccoli (150 ml of water) for 3 minutes in a microwave at 800 W, the content of sulforaphane is depleted already within the first minute. At 900W, sulforaphane peaks between 30-45 seconds, minimizing nitrile production, but after the first minute, sulforaphane is also affected. Boiling broccoli in 1.5 liters of water deactivates myrosinase after only 1 minute, and the authors of the experiment concluded that if broccoli is not immersed after 30 seconds of heating in ice water (to reduce the effect of heat after being removed from the water), this method of boiling is hardly possible. attributed to adequate retention of sulforaphane in the product afterwards. When steaming sulforaphane-containing products, the content of the substance peaks between 1-3 minutes, and completely disappears after 5 minutes, without sufficient formation of nitrile. Thus, steaming sulforaphane-containing foods is the most suitable method for preserving sulforaphane, microwave cooking is the second most efficient, and boiling broccoli is a highly inefficient way to preserve sulforaphane. When comparing the biological value of fresh and frozen broccoli, it turned out that the content of sulforaphane in fresh broccoli is 10 times higher than in frozen, which indicates a negative effect of cold on myrosinase.

Molecular targets

H2S

Hydrogen sulfide is one of the three most important gas transmitters in the human body (transmit molecules that are in a gaseous state), along with nitric oxide and carbon monoxide. Hydrogen sulfide is one of the main active ingredients of garlic. Cruciferous vegetables usually have a strong odor of H2S when cooked, and since the cardio-protective effects of garlic are due to the sulfur content and sulforaphane has similar properties, sulforaphane was found to release H2S in prostate cancer cells and a 10µm mouse liver homogenate. It can be assumed that any molecule with an isothiocyan group (-N=C=S) can act as a sulfur-containing molecule with the release of H2S. Sulforaphane is able to activate hydrogen sulfide in the body when taken orally, from which it can be concluded that the mechanisms of action are similar to taking garlic.

Pharmacology

assimilation

Sulforaphane is a well-absorbed drug, which has been confirmed by multiple human trials - after consumption of broccoli, active excretion of sulforaphane in the urine was observed. In humans, the biological value of sulforaphane is 74%, and the absorption of sulforaphane mainly occurs in the small intestine.

Serum

In rats, oral administration of 50mol sulforaphane (8.8mg; or 58-73mg per kilogram of body weight) appears within an hour and peaks at 20µm 4 hours after ingestion; is accompanied by a half-life of 2.2 hours and reaches the initial level of sulforaphane content 12 hours after administration.

Cytology and transportation

Sulforaphane quickly penetrates the cells and accumulates in them. It quickly conjugates with glutathione and glutathione-S-transferase, which contributes to its accumulation; Sulforaphane readily conjugates with glutathione and forms dithiocarbamate conjugates such as glutathione-sulforaphane. The cellular concentration of sulforaphane may exceed the serum concentration, because, according to one study of incubation of cultures with 0.028-0.28mM sulforaphane, the cellular concentration was 4.4-13.3mM, which is 47-145 times higher than the accumulation within 2 hours of the total content of sulforaphane and conjugated sulforaphane. According to this study, there was an 8% drop over the next four hours when the cells remained in the culture medium, but there was a large release of sulforaphane-glutathione conjugates when the medium did not contain sulforaphane. This efflux was inhibited by MRP protein inhibitors (54-73% remained inside the cell) and less by P-glycoprotein inhibitors (38-39%; in the control group - 30%). Sulforaphane accumulates rapidly in cells, which may exceed the value in blood serum; cell efflux is mediated primarily by MRP proteins and, to a lesser extent, by P-glycoproteins. When tested in rats, sulforaphane was found in all tissues studied in the brain, prostate, liver, colon, lungs, kidneys, and small intestine mucosa, as well as in plasma. Liver, brain, and kidney levels peaked 2 hours after gavage with little attenuation at 4 hours, while lung levels decreased after 4 hours; all other tissues peak at 2 hours and higher concentrations at 4 hours, with most sulforaphane excreted from all tissues within 24 hours of ingestion. Tissue concentrations vary, but the lowest concentration is observed in the brain; a difference of more than 100 times was noted.

Enzyme Interactions

Sulforaphane is able to inhibit the induction of CYP1A1 (aromatase) caused by benzo(a)pyrene components benz(a)pyrene when incubated at 0.5-2.5µm in HepG2 cells and is ineffective on CYP1A1 / 2 in MCF7 cells, with simultaneous administration of sulforaphane and benzopyrene ; sulforaphane attenuates the increase in CYP1A caused by the previous concentration of benzo(a) pyrene. The maximum inhibition was 30% CYP1A per 0.5µm and 14% CYP1B per 1µm. The attenuation of aromatase was secondary to the prevention of nuclear translocation of the aryl hydrocarboxylic receptor (AHR) at a concentration of 0.5-1 μM. Sulforaphane is a weak agonist and non-competitive aryl hydrocarbon receptor antagonist and does not compete with the aryl hydrocarbon receptor. By preventing more potent agonists from binding to the aryl hydrocarbon receptor, sulforaphane reduces the genetic transcription of the aryl hydrocarbon to its reporter and prevents agonist-induced upregulation of aromatase and any cancerous process mediated through the aryl hydrocarbon receptor. This antagonism is independent of concentration.

neurology

Pharmacokinetics

Sulforaphane can be found in the neuronal tissues of rats after administration of 5umol (0.88mg; 19.36mg/kg) and 20umol (3.52mg; 77.44mg/kg) and after 2 and 6 hours, respectively, the concentration in the brain tissues and blood serum was 0.72-0.77 with the lowest score of 0.59 after 6 hours, when sulforophane had already been removed from the body; after 24 hours from the moment of injection, sulforaphane was not detected in the brain tissues. Despite the serum levels, the neuronal concentration of oral sulforaphane is low and ranges between 0.002-0.003 mg/g dry matter relative to the doses described above. The concentration of the substance in the brain cells correlates well with the concentration in the blood, however, there may be problems in crossing the blood-brain barrier, since the concentration of the substance in the brain of rats after oral administration remained at a low level.

Nerves

The incubation of nerve cells with sulforaphane allows protection from oxidation by a high concentration of glucose, induction of Nrf2, HO-1 and NOQ1. Also, sulforaphane has an anti-inflammatory effect by inhibiting Nf-kB, which was confirmed by laboratory tests on rats that were orally administered 1mg/kg sulforaphane and sciatic nerve readings were measured after 6 weeks.

Addiction

Inhibition of histone deacetylase reduces cocaine addiction in mice (sucrose does not have a similar effect), which was found with trichostatin A (often used in various studies of sulforaphane). However, no studies have been conducted to date on the effects of sulforaphane on cocaine addiction. There is a possibility that sulforaphane can affect cocaine addiction, but this fact has not yet been studied.

Impact on life expectancy

Mechanism of influence

The rejuvenating mechanism of action of sulforaphane is to influence the activity of the protiasome and reduce the accumulation of modified proteins; a decrease in the activity of this system affects the aging of cells. It was found that sulforaphane is able to activate the response to heat shock through selective overexpression of HSP27 at a concentration of 7.5-10 μm through the translocation of Hsf1, which increases HSP27. It should be noted that heating does not affect Nrf2 activity. Activation of the PSMB5 subgroup of the 26S proteasome by sulforaphane is a consequence of Nrf2 activation as a result of an element of the genomic antioxidant response; is the fundamental mechanism of action of sulforaphane. Sulforaphane-induced proteasome activity is chymotrypsin and caspase, but not trypsin, in multiple cell lines without apparent apostosis. Since HSP27 silencing blocks growth and activity due to HSP27 induction in vitro, it is HSP27 that modulates sulforaphane-induced proteasome activity. Sulforaphane is also able to increase the stimulation of mitogen-activated protein kinase (including externally regulated kinase and p38) that phosphorylates HSP27, but this phosphorylation does not promote proteasome activity.

Obesity and overweight

Mechanisms of influence

Sulforaphane is able to increase the production of glycerol in the medium (during the breakdown of fats) in amounts dependent on the concentration of sulforaphane up to 10 µm, simultaneously with an increase in hormone-sensitive lipase, mRNA and CPT1A mRNA, has no effect on pyrilipin or ATGL mRNA. Sulforaphane is usually associated with hormone-sensitive lipase or Ser563, as indicated by deactivation of AMP-dependent kinase by phosphorus Thr172 and indirect activation of hormone-sensitive lipase; The release of glycerol under the influence of sulforaphane is reduced when interacting with activators of AMP-dependent kinase, and phosphorized AMP-dependent kinase was reduced by 20% at 5-10 microns of sulforaphane. AMP-dependent kinase can directly influence the release of glycerol, which leads to fat burning, however, its decrease can also affect the same after an increase in CPT1A, as a result of component C (AMP-dependent kinase inhibitor). The practical significance of the above studies has not been confirmed. Other studies highlight Nrf2, the target of sulforaphane, which is naturally antioxidant (because it activates elements of the genomic antioxidant response), involved in the regulation of fat cells (it is possible that the data is not correct, since they are rather inconsistent). Both "turning off" and "on" them reduces the growth of adipocytes (which can be accompanied by negative health consequences, such as insulin resistance). A decrease in Nrf2, the protein NAD(P)H:quinone oxidoreductase (not to be confused with NADPH oxidase, the target of spirulina) at a 10.5-fold increase and in the presence of sulforaphane at a dose of 5-20 microns, can reduce the accumulation of triglyceride in fat cells. Theoretically, it can be used against obesity, but these claims also do not have a practical basis.

Effects on skeletal muscles

Myostatin

Acting as a histone deacetylase inhibitor, sulforaphane can inhibit myostatin transcription and suppress the negative effect of myostatin suppression in porcine satellite cells. However, such effects on satellite cells may not be affected because sulforaphane regulates TGF-β/Smad by signaling differentially based on the state of the cells. The above results from studies in pigs suggest that sulforaphane and the reference drug 5-aza-2′-deoxycytidine inhibit myostatin, but not trichostatin A (another histone deacetylase inhibitor). Sulforaphane at concentrations of 5, 10 and 15µm (by oral administration) did not increase the concentration of follistatin (a natural myostatin antagonist), however, an increase in Smad7 and Smurf1 mRNA was noted, with a limit of 5µm. MicroRNA, which increased the content of myostatin, was reduced only in miR-29a and miR-29b. In one study of skeletal muscle satellite cells, a loss of signal for the presence of myrostatin was observed, which was caused by an interaction with sulfarofan histone deacetalase or an Nrf2 inhibitor; the practical relevance for the use of sulforaphane in muscular hypertension is unknown. Interestingly, this study showed a significant decrease in MyoD mRNA levels at 10µM (5µM concentrations were not evaluated) in porcine satellite cells, as well as a decrease in myostatin binding via binding site hypoacetylation.

Effects on glucose metabolism

Type 1 diabetes

In an animal model of type 1 diabetes (induced by streptozotocin), oral administration of 0.1, 0.25, or 0.5 mg/kg sulforaphane for three days prior to injections of streptozotocin was noted to attenuate changes in body weight one week after injection. liver and body as a whole, and completely normalized changes in blood glucose levels and insulin sensitivity.

Immunology and inflammatory effect

Mechanisms of influence

Sulforaphane is able to act on the prototypical anti-inflammatory mechanism by slowing down NF-kB translocation, which blocks the transmission of inflammatory signals to the nucleus. In studies using macrophagocytes (RAW 264.7 cell line), lipopolysaccharide-induced inflammation was attenuated by sulforaphane with an IC50 value, and NO, TNF-α, and PGE2 production was reduced to levels of 0.7uM, 7.8uM, and 1. 4 µm respectively. The mechanism of action of sulforaphane in slowing down NF-kB translocation is not due to a direct effect on the inhibitory unit IκB-β (which keeps NF-kB in a passive state), but by slowing down the production of IκB-α. Sulfarofan is also able to directly inhibit the formation of NF-kB complexes in the nucleus. The anti-inflammatory properties of sulforaphane are due to the suppression of NF-kB translocation to the nucleus, which prevents the transmission of inflammation signals from the cytosol and blood serum to the nucleus. Sulforaphane can act as an inhibitor of thioredoxin reductase in lipopolysaccharide-stimulated macrophagocytes, which may serve to enhance the effect of sulforaphane on NF-kB, since thioredoxin is able to increase NF-kB activity in pro-inflammatory conditions. In this regard, sulforaphane and the agent CDNB (irreversible thioredoxin reductase inactivator) are synergistic. In non-immune and non-lipopolysaccharide-stimulated cells, thioredoxin levels can be increased by activating a genomic antioxidant element response via Nrf2 activation; thioredoxin induction was manifested by injections of 0.5 mg/kg sulforaphane (physiologically significant concentration). Thioredoxin reductase is the molecular target of PQQ, whose interaction with sulforaphane is unknown.

Rheumatoid arthritis

Rheumatoid arthritis is characterized by inflammation and a rapidly proliferating synoviocyte. Treatment methods are currently being studied. In vitro, sulfarofan succeeded in suppressing TNF-α-induced inflammatory effects and proliferation and inducing cell apostosis in already stimulated TNF-α.

Impact on cancer

Mechanisms of influence

Sulfarofan may act as a histone deacetylase inhibitor, which may promote the expression of p21Cip1/Waf1 through deacetylated histones H3 and H4. The activity of sulfarofan at 15µm is comparable to standard Trichostatin A at 100ng/mL and has an addictive effect when co-incubated; since they do not affect either the histone deacetylase protein or β-catenin, they probably function by suppressing the action of TOPflash, which leads to at least a doubling of acetylation relative to histones H3 and H4. In this regard, sulforaphane does not function by itself, but through metabolites, and is effective at a uniform concentration of sulforaphane-cysteine ​​and sulforaphane-NAC. Sulforaphane acts as a histone deacetylase inhibitor and is concentrated in the blood serum.

Prostate

When taken orally at 1.55-6.2 mg/kg (human dose based on studies in mice) of sulforaphane, the drug is concentrated in the prostate in volumes of 0.07-0.01 mg/g 2-6 hours after ingestion, although this does not match the content in blood serum. The effect of sulfarofan on the prostate when taken orally is confirmed, the process of bioaccumulation occurs at a concentration corresponding to the mechanism of action of the drug. Sulforaphane promotes the release of free hydrogen sulfide (H2S) into prostate cancer cells, and concentrations of sulforaphane of 5-50uM result in the release of H2S (via cystathionine gamma lyase) as well as a decrease in cancer cell resistance. H2S, like sulforaphane, activates all three critical mitogen-activated protein kinases (ERK, JNK, p38) and prevents blocking the effects of H2S. Thus, activation of mitogen-activated protein kinases by sulforaphane is achieved by hydrogen sulfide (H2S). Histone deacetylase 6 (HDAC6) is a protein capable of degrading the HSP90 cytosolic chaperone, and this disruption dysregulates the androgen receptor and, through this receptor, attenuates signals at a concentration of 10-20uM; this is mediated by HSP90 hyperacetylation from HDAC6 inhibition. Sulforaphane does not reduce transcriptional activity, suggesting that inhibition occurred post-transcriptionally by downregulating the androgen receptor in the LNCaP and VCaP prostate cancer cell lines, while BPH-1 and PC-3 cells indicated an increase in the androgen receptor in prostate cancer. Mechanically, sulforaphane inhibits HDAC6 activation, reducing the ability of anrogens to signal through the prostate. Since androgens may promote the survival of prostate cancer cells, the mechanism of action is considered negative. Interestingly, research is currently underway on a synthetic analogue of sulforaphane called D,L-sulfarofan and its effect on prostate cancer, the results may be promising. In laboratory studies, sulfarofan inhibited the growth of cancer cells and led to their apoptosis. One study on the possibility of nutrient interactions noted that curcumin and green tea catechins tested for LNCaP and sulfarofan, which when paired with two sulfarophane-containing dietary supplements, sulfarofan had a positive effect on reducing cell proliferation. Simultaneous intake of curcumin, green tea catechins and sulforaphane shows positive results in reducing the growth of prostate cells.

Cancer of the rectum and colon

In one study using Caco-2 cells, it was noted that sulforaphane incubation increased the mRNA content of the TGF-β receptor, its two subunits (receptors I and II), and enhanced SMAD2/3 signals upon stimulation of these receptors, enhancing the apoptotic effect in these cells. . Previously, broccoli extract has been used to suppress Smad2 phosphorylation, which disputes the above data.

Impact on other organs

kidneys

The concentration of sulforaph in the kidneys after oral administration reaches 0.06-0.07 mg / g 4-6 hours after ingestion, which indicates the accumulation of the substance in the kidneys when taking this biological supplement. When mice were fed sulforaphane at 0.5mg/kg bw for 3 months, there was significant progress in the suppression of renal failure (as measured by renal albumin weight: creatine levels, which reached normalization in diabetic and control mice of 41% and 37.7% respectively) in diabetic mice after sulforaphane intake alone. This effect was due to the activation of Nrf2, which suppressed oxidative and inflammatory factors, which also protected the kidneys from organotoxins (similar to the effect of curcumin), unilateral ureteral obstruction, diabetic nephropathy, ischemia, reperfusion, and exposure to ciplatin. Sulforaphane is effective tool to protect the kidneys during periods of intoxication or physical intervention, improvements can only be seen for the period of use of the drug.

Liver

One study using streptozotocin to suppress type 1 diabetes found that dietary sulforaphane at a dose of 0.05-0.5 mg/kg before injection aggravated some liver damage by increasing AST (not ALT) and overall cholesterol (but not HDL-C or hepatic triglycerides; serum TGs were significantly reduced to control levels).

Nutrient Interactions

Curcumin

Sulfarofan and curcumin mutually reinforce each other's inflammatory action in macrophagocytes, since the level of anti-inflammatory effect when taking each substance separately is comparable when these substances are taken simultaneously at a concentration of up to 40% of the initial one. This mutually reinforcing effect depends on the level of influence on the antioxidant protein of mRNA HO-1 and NQO1. Another study measured the apostosis rate of pancreatic cancer cells (PaCa-2 and Panc-1) using sulforaphane, curcumin, and aspirin at doses of 5µm, 2.5µm, and 25µm, respectively.

Phenethyl isothiocyanate

Phenethyl isothiocyanate is, along with sulfarophane and diindolylmethane, another component of cabbage plants and mutually enhances the action of the above substances. In studies with macrophagocytes (RAW 264.7, immune cells), phenethyl isothiocyanate was found to have similar efficacy to curcumin in blocking inflammation from macrophagocytes (measured as nitric oxide; IC80 at 5µm respectively) while sulforaphane was more active with an IC80 at 1µm ; the synergistic properties of sulforaphane and phenethyl isothiocyanate were better than those of sulforaphane and curcumin, and the 40% combination (2µm phenethyl isothiocyanate and 0.4µm sulforaphane) was as effective as the drugs alone, but at a higher concentration .

Neoglucobrassicin

Neoglucobrassicin, along with phenethyl isothiocyanate and sulforaphane, is another broccoli glucosinolate found in small amounts in offshoots and large amounts in ripe broccoli, as is sulforaphane. Under laboratory conditions, neoglucobrassicin and its metabolites interfere with sulforaphane signaling through Nrf2, which determines glutathione induction. The metabolites themselves do not stimulate Nrf2. Although the practical significance of this is unknown, neoglucobrassicin may reduce the beneficial effects of sulfarofan on Nrf2 (drown out the effects of the antioxidant).

Mustard

Glucoraphanin becomes hydrolyzed by the enzyme myrosinase and then produces one of two metabolites, 5-methylsulfinylpentane nitrile or sulfarophane. When heated at low temperatures, glucoraphanin is able to increase the production of sulfarofan by inactivating ESP. High temperatures interfere with mirazinase and prevent the formation of another metabolite. Due to this balance (when cooked, myrosinase usually loses its natural properties), it has become popular to add mustard to broccoli, since myrosinase is more heat-resistant than broccoli. Therefore, while mixing mustard powder with broccoli powder (1-2%; or 12-25mg per 150mg broccoli powder), sulforaphane's cooking utility is increased, and anything that would evaporate at 60 degrees Celsius now has a 90-degree threshold. When boiling broccoli for 8-12 minutes, 3 times more sulfarofan is preserved when adding mustard seed. Based on the above, it can be concluded that it is better to mix mustard and broccoli than to cook them separately, however, when growing these two plants close to each other, a similar effect is not observed.

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List of used literature:

Nakagawa K, et al. Evaporative light-scattering analysis of sulforaphane in broccoli samples: Quality of broccoli products regarding sulforaphane contents. J Agric Food Chem. (2006)

Matusheski NV, et al. Preparative HPLC method for the purification of sulforaphane and sulforaphane nitrile from Brassica oleracea. J Agric Food Chem. (2001)

Matusheski NV, Juvik JA, Jeffery EH. Heating decreases epithiospecifier protein activity and increases sulforaphane formation in broccoli. Phytochemistry. (2004)

Furniss CS, et al. Polyamine metabolism and transforming growth factor-beta signaling are affected in Caco-2 cells by differentially cooked broccoli extracts. J Nutr. (2008)

Wang GC, Farnham M, Jeffery EH. Impact of Thermal Processing on Sulforaphane Yield from Broccoli (Brassica oleracea L. ssp. italica). J Agric Food Chem. (2012)

Benavides GA, et al. Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci U S A. (2007)

Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system

Vermeulen M, van Rooijen HJ, Vaes WH. Analysis of isothiocyanate mercapturic acids in urine: a biomarker for cruciferous vegetable intake. J Agric Food Chem. (2003)

In Vivo Pharmacokinetics and Regulation of Gene Expression Profiles by Isothiocyanate Sulforaphane in the Rat

Zhang Y, Talalay P. Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes. Cancer Res. (1998)

Zhang Y, Callaway EC. High cellular accumulations of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. Biochem J. (2002)

Skupinska K, et al. Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo(a)pyrene. J Biochem Mol Toxicol. (2009)

Anwar-Mohamed A, El-Kadi AO. Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells. Cancer Lett. (2009)

The Aryl Hydrocarbon Receptor Nuclear Translocator (Arnt) is required for tumor initiation by benzo(a)pyrene

Clarke JD, et al. Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. PharmRes. (2011)

Negi G, Kumar A, Sharma SS. Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes. Curr Neurovasc Res. (2011)

Broccoli extract(eng. Broccoli extract) is, for the most part, a substance known in pharmacology as sulforaphane, but not only. It is part of the cruciferous plants, but the largest amount of it is in broccoli. Extract has antitumor and anti-inflammatory properties, removes toxins from the body and balances the level female hormones slows down the development of diabetes.

Interesting Facts! The first mention of broccoli dates back to the 1st century BC, the Roman scientist Pliny, describing the plant, called it "blessed". Broccoli is very fond of in the USA, because it was not for nothing that the well-known Hillary Clinton, campaigning for the election of her husband, held a banner with the inscription: "Let broccoli return to the White House."

Broccoli extract: production

Broccoli is rich in phytochemicals collectively known as glucosinolates, one of them being glucoraphanin. In the mouth while chewing broccoli, under the action of myrosinase, glucoraphanin is broken down. As a result, it is formed, in which the most valuable substance is sulforaphane. To get that amount extract, which is necessary for the body to prevent and treat many ailments, you need to eat about 500 g of raw broccoli daily. It's no secret that not everyone likes the taste of broccoli. Therefore, it is recommended to take sulforaphane in the form of dietary supplements that contain broccoli sprouts, the enzyme myrosinase and glucosinolates.

Broccoli extract: composition

Compound broccoli extract can be compared with a complete natural multivitamin complex. The content in broccoli exceeds its performance in citrus fruits, and the amount is equal to that of carrots and pumpkin.

Part extract includes:

• vitamins A, B9 (), U;
• bioflavonoids;
• , phosphorus, sodium, iodine, iron, chromium, boron and;

Broccoli extract: medicinal properties

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Main value broccoli extract are its anti-cancer capabilities. Sulforaphane has a high antioxidant activity, protects cells from damage.

1. Slows down the aging process of the brain, prevents the development of Alzheimer's disease.
2. Helps diabetics to lower blood sugar levels.
3. Reduces the level of bad cholesterol in the blood.
4. Extract is a natural anticoagulant, prevents the appearance of blood clots.
5. Helps lower blood pressure.
6. Prevents the development of neurodegenerative diseases that underlie stroke and complications after traumatic brain injury.
7. Improves liver function.
8. Supports the work of the heart.
9. It also has anti-inflammatory properties.
10. Increases intestinal activity, and similarly, and contributes.

It has an undoubted benefit in atherosclerosis, removing toxic substances from the body and lowering cholesterol. There is data that extract slows down the aging process.

Broccoli extract: application

1. as an aid in dietary nutrition;
2. to restore weakened immunity;
3. is part of sports nutrition;
4. as well as used in the treatment of oncology;
5. to restore liver function;
6. to normalize metabolism and remove toxins from the body and;
7. as a preventive measure and to maintain vitality;

Useful information! Scientists from the Swedish University of Gothenburg have identified a positive effect broccoli extract in the treatment of type 2 diabetes. They found that sulforaphane suppresses the activity of genes that provoke the development of diabetes. An experiment was conducted on 100 volunteers with this disease. Result: The supplement actually lowers blood sugar levels without causing digestive problems. Clarification: extract reduces glucose levels only in people who have.

Broccoli extract: action, effect on the body

Broccoli extract(sulforaphane - the active substance) activates specific genes that are responsible for protecting the body from the occurrence of malignant tumors. Sulforaphane has a rejuvenating effect on the body, it reduces the activity of the aging system.

Scientific fact! Young sprouts and seeds of broccoli are hundreds of times more biologically active than fully mature plants. Consequently, extract made from seeds and sprouts is more effective than fresh cabbage.

Broccoli extract: together with indole-3-carbinol

Broccoli extract is another source that is broccoli glycosinolate. Indole-3-carbinol is also broccoli extract, it protects the body from the negative effects of the external environment, from age-related changes in the body and from the consequences of an unhealthy lifestyle. Indole-3-carbinol complements the detoxifying and antitumor properties of sulforaphane. The bioadditive is also made on the basis of indole-3-carbinol.

Broccoli extract: for skin

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Broccoli extract included in many cosmetics for skin care. Extract has an antioxidant effect on the skin, as well as:

1. relieves irritation;
2. protects against UV rays;
3. brightens and tones;
4. prevents the destruction of collagen;
5. has an astringent and anti-inflammatory effect.

Sulforaphane activates the glyoxalase system, which is responsible for the rate of aging of the body, thereby slowing down the appearance of wrinkles. Extract is part of sunscreen cosmetics.

The tool is suitable for any skin, but is especially effective for age-related, lost skin tone. Vitamin E and lutein in the composition broccoli extract help maintain the natural beauty of the skin.

Broccoli extract: sheet mask

Sheet masks are great for keeping skin healthy and clear. broccoli extract. Mask made of dense fabric impregnated with natural extract. Imposed on a clean steamed face, it is left for 20-30 minutes. During this time, all the natural components of the mask are absorbed into the deepest layers of the dermis, moisturize and saturate it with nutrients. The mask contains no artificial ingredients, even talc. After the time has elapsed, the mask is removed, and the remnants of the substance can be distributed over the face and gently rubbed until completely absorbed. The mask itself is recommended to be folded in half and applied to the neck area for 20 minutes, it is not necessary to wash off the remnants.

Broccoli extract: for breasts

In oncological diseases, cells degenerate, in particular, in the mammary glands. Anti-cancer qualities broccoli extract help in the complex treatment of breast cancer in women. Scientists from the University of Michigan have found that sulforaphane not only destroys cancer cells, but also stops the formation of new tumors. In the course of research, it was revealed that it blocks only cancer cells, without affecting healthy tissues.

Broccoli extract: with mastopathy

Mastopathy is a disease of the mammary gland, in which there is an increase in the internal tissue, small painful seals appear, initially of a benign nature. Broccoli extract has an antitumor effect and helps in the treatment of mastopathy. The drug relieves pain and normalizes tissue growth, inhibits the degeneration of benign cells. The use of the drug is effective already at an early stage of the disease, extract eliminates signs and stops the growth of the endometrium.

Broccoli extract: menstruation

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Due to the presence of folic acid in the composition, it has a positive effect on women's health in general. The drug balances the level of female sex hormones, normalizes the monthly cycle, alleviates negative symptoms during menopause. It also relieves mood swings and poor health during PMS.

Broccoli extract: endometriosis

In application reviews broccoli extract Patients note positive dynamics in the treatment of endometriosis. With this disease, the cells of the inner walls of the uterus grow, this causes severe pain and leads to infertility. After taking the drug, ultrasound showed that the growth of neoplasms had stopped, and the existing ones had significantly decreased in size. Treatment of such serious ailments is best done under the supervision of a doctor, but the fact remains that extract helps in the treatment and prevention of tumors of various locations.

Broccoli extract: for gastritis

It is known that the Helicobacter pylori bacterium is recognized as the main cause of gastritis. Scientists have found that the systematic use broccoli extract destroys these harmful bacteria.

Action of components broccoli extract on the body with gastritis:

• antioxidants help heal wounds on the mucous walls of the stomach, activate its work;
• vitamin C relieves inflammation;
• (vitamin A) restores and normalizes the work of the stomach and intestines.

Important! Broccoli extract with gastritis, it is recommended to take it in the form of food supplements, since eating fresh broccoli, on the contrary, can lead to a complication of the disease.

Broccoli extract: for the liver

Broccoli extract used to treat and restore a diseased liver. The drug is recommended for recuperation after liver surgery. Broccoli extract effective as a prophylaxis for fatty liver, which leads to oncology. Indole-3-carbinol helps to remove toxins from the body, thereby removing the very causes of the disease.

Broccoli extract helps to cope with the consequences of alcohol abuse. It will speed up the removal of alcohol residues, soften the signs of a hangover.

Broccoli Extract: Now Foods

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1. Firm Now Foods produces food supplement Real Food, Broccoli Seeds (113g, 4oz).

The company represents the most useful organic, healthy products. Products are broccoli seeds for subsequent germination. The seeds contain:

• sodium, protein;
• vitamin A, vitamin C;
• calcium and iron;
• dietary fibre.

Recommendations for use: Soak 1 tablespoon of seeds overnight, drain excess water in the morning and place the seeds in a wide container for germination. For 3 days, put the container in a dark place, on the fourth day, transfer it to light for chlorophyll to enter. Rinse seedlings daily and change water. Sprouts are ready for use in 3-5 days. You can eat them alone or add them to salads. So that mold does not appear during germination, you can add 0.5 teaspoon of citric acid.

Broccoli Extract: Source Naturals Tablets

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1. Broccoli extract in tablets "" (500 mg, 60 tablets) manufactured by the company Source Naturals .

Activated Broccoli Seed Extract: in Solaray capsules

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1. Firm Solaray represents Activated broccoli seed extract"Activated Broccoli Seed Extract" (350 mg, 30 vegetable capsules).

The dietary supplement is guaranteed to contain 10% sulforaphane glucosinolates and provides the activity of the myrosinase enzyme. The drug is suitable for vegetarian diet, has passed laboratory tests. Each capsule contains myrosinase enzyme and organic broccoli sprouts.

Broccoli extract: in the pharmacy

It is very difficult to buy natural in a regular pharmacy, as there is a high risk of purchasing a fake or a product with a low concentration of sulforaphane. In this drug, the dosage is very important. Included in the product additional components reduce the concentration of the active substance and make the drug ineffective. Therefore, it is preferable to buy dietary supplements on trusted sites. A link to one of them is given below.

Broccoli extract: instruction

Broccoli extract available in the form of tablets, capsules and seeds for sprouting. If there is little trust in tablets, then you can germinate the seeds yourself, but one circumstance must be taken into account. The tablets contain the daily rate of sulforaphane, and taking sprouts, it is difficult to determine such a dosage.

Broccoli extract how to take

It is recommended to take 2 micrograms of sulforaphane per day. Usually, this amount is contained in 2 tablets or 1 capsule broccoli extract. You can take the drug at any time, washed down with 1 glass of water or combined with a meal.

Broccoli extract: contraindications

Broccoli extract fully natural product without causing side effects. But there are a few restrictions. It is not recommended to take the drug when:

• with increased acidity of the stomach;
• with individual intolerance;
• with serious diseases of the gastrointestinal tract.

Broccoli extract: reviews

Feedback on the application broccoli extract There are many positives and negatives on the net. Negative reviews are mostly based on the high cost of the drug, people consider it overpriced and not accessible to everyone. Users who took the dietary supplement noted a decrease in sugar in diabetes, a general improvement in well-being. Doctors also note positive changes in the well-being of patients after taking the course. extract. Buyers write about the positive dynamics in the treatment of gastritis, the normalization of the cycle in women.

Broccoli extract: price

Prices are high in almost all points of sale. But keep in mind that products Russian production usually produced with a low concentration of the main substance due to additives. You can buy drugs of proven quality 2-5 times cheaper on a popular site by clicking on the link below. Here you can order high-quality drugs for the treatment and prevention of oncology: and available to you! 10% discount for new customers and promotions up to 30% for existing customers! We recommend that you definitely use it, because. on the second order, you can also count on discounts or return part of the funds through, who will try to return the percentage of the purchase at already low prices! Also look at promotions and sales, for example, on or on many products.
4. Detailed articles about the intricacies of delivery and payment: and !

How does it help you? Your feedback or advice is very important for beginners and people suffering from similar ailments!

I want to touch on a not very fun, but very important women's topic - breast health. This is useful to know not only for women of my age, but especially for young girls. Most recently, the doctor told me that the ideal medicine and prevention from all sorts of sores such as mastopathy is broccoli. It is a pity that I did not know this before, it could have avoided many problems.

Have you heard that all diseases are caused by nerves? We often hear it, but we don't take it seriously. Being young, and I did not attach any importance to this. Excellent health, positive attitude, energy has always led me forward. Where am I nervous? Well, I had a fight at work, stood in a traffic jam, didn’t share something with my girlfriend - was it nerves, it seemed to me. And so it was for quite a long time. And then - bam.

The trouble came unexpectedly, but according to the standard scheme: the lymph nodes swelled, the chest ached and seemed very heavy. And in the end, I began to feel some bumps inside, in general, I was frightened in earnest. There is so much talk about breast cancer right now that I almost brought myself to hysterics. Thank God, nothing terrible was found, they diagnosed cystic mastopathy and fibroadenoma. For some time I drank mastodinone, Alfity ... the pain became less, but according to the results of the ultrasound, the doctor did not see any improvement (but also worsening).

This situation did not suit me and I began to look.

In short, it turns out that broccoli contains the substance sulforaphane. It is it that has an antitumor effect and helps to cope with various breast diseases. It is enough to eat broccoli dishes or preparations containing broccoli extract 2 times a day. It also contains other anti-cancer components: sinegrin and indole. I physically cannot eat cabbage all day long, so I went, so to speak, by artificial means. Bought Indole from Evalar(costs about 300 rubles, enough packaging for half a month) and ordered women's vitamins Nature's Way DIM-plus, which also have broccoli (they cost 1200).

To be honest, I didn’t expect anything from Indol, since the Evalar brand does not inspire confidence in me, but there is a result. What was called a fibroadenoma turned out to be a cyst and it resolved in six months (my joy knew no bounds!), And in general, a year later I forgot that something swelled and pulled me there.

Of course, do not forget about vitamins.

I must say right away that from Indol at first it is small side effect in the form of a digestive disorder, but this should pass in a week, if not, then the drug is not suitable for you.